Helix-turn-helix is a DNA-binding protein (DBP). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene … See more The discovery of the helix-turn-helix motif was based on similarities between several genes encoding transcription regulatory proteins from bacteriophage lambda and Escherichia coli: Cro, CAP, and λ repressor, which were found to … See more The helix-turn-helix motif is a DNA-binding motif. The recognition and binding to DNA by helix-turn-helix proteins is done by the two α helices, one … See more • DNA-binding domain • DNA-binding protein • Secondary structure See more • Helix-turn-helix motif, lambda-like repressor, from EMBL • Full PDB entry for PDB ID 1LMB • Cro/C1-type HTH domain, more HTHs in PROSITE See more Several attempts have been made to classify the helix-turn-helix motifs based on their structure and the spatial arrangement of their helices. Some of the main types are described below. Di-helical The di-helical helix … See more • Struhl K (April 1989). "Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins". Trends in Biochemical Sciences. 14 (4): 137–40. See more WebHelix-Turn-Helix Motif. Helices 2 and 3 form the highly conserved HTH structural motif. This motif is comonly found in bacterial and bacterialphage regulatory proteins. This domain, …
Online Analysis Tools - Motifs
WebA two-sided β-helix (right-handed) is found in some bacterial metalloproteases; its two loops are each six residues long and bind stabilizing calcium ions to maintain the integrity of the structure, using the backbone and the Asp side chain oxygens of a GGXGXD sequence motif. This fold is called a β-roll in the SCOP classification. WebThe gntR product is 331 amino acids long, with a helix-turn-helix motif typical of a regulatory protein [24]. The mutation in strain PAT-2 is the deletion of G at nucleotide … college students who work full time
HELIX-LOOP-HELIX, HELIX-TURN-HELIX - SlideShare
WebThe helix-turn-helix motif was originally identified as the DNA-binding domain of phage repressors. One alpha-helix lies in the wide groove of DNA; the other lies at an angle across DNA. Usage Here is a sample session with helixturnhelix % helixturnhelix Report nucleic acid binding motifs Web2.5 Helix-turn-helix. The loop regions connecting alpha-helical segments can have important functions. On example is the EF hand. In parvalbumin there is a helix-turn-helix … WebA structural motif found in a number of proteins (some of the DNA-binding regulatory proteins) in which leucyl residues align along one edge of the helix and can interdigitate … college students working during college